Take the main East exit (for Kabukicho) of JR Shinjuku station. Go left down Chuo Dori which is just on the left of Alta. Keep walking straight, cross the big crossing and into Kabukicho, keep going straight until you reach a T-Intersection with Toho Cinemas in front of you. Turn right, then immediately left, and when you get to the intersection look for the sign for Loft in the white Tatehana building on the right corner with lots of host bars. It's in the basement.
tel 03-5272-0382